Team:Evry/LogisticFunctions

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<p><img width="80%" src="https://static.igem.org/mediawiki/2013/0/05/CourbeLogistique.png"/></p>
<p><img width="80%" src="https://static.igem.org/mediawiki/2013/0/05/CourbeLogistique.png"/></p>
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<h2>Differential form:</h2>
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<p>Let the following be a Cauchy problem:
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y: x → y(x) a real function
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y' = b*y*(1-y/K)
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y(0) = p
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</p>
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<p>The solution of this Cauchy problem is as below:
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y(x) = K/(1+(K/p – 1)*e^-bx)
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</p>
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<p>Here is our logistic function. Yet, differential equations are not always time-related.
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Let x be a temporal function, and y be a x-related logistic function. In order to integrate y into a temporal ODE, we need to write it differently:
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dy/dx = by(x(t))(1 – y(x(t))/K)
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<=>( dy/dt)/(dx/dt) =  by(x(t))(1 – y(x(t))/K)
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</p>
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<p>And so:
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dy/dt = dx/dt *  by(x(t))(1 – y(x(t))/K)
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If t → x(t) is a continuous real function, then:
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y(x(t)) = y(t)
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Finally,
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dy/dt =  dx/dt *  by(1 – y/K)
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</p>
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Revision as of 15:13, 29 September 2013

Iron coli project

Logistic functions :

When we started to model biological behaviors, we realised very soon that we were going to need a function that simulates a non-exponential evolution, that would include a simple speed control and a maximum value. A smooth step function.

Such functions, named logistic functions were introduced around 1840 by M. Verhulst.

These functions looked perfect, but we needed more control : we needed to set a starting value and a precision.

Parameters:

  • Q : Magnitude.
             The limit of g as x approaches infinity is Q.
  • d : Threshold.
             The value of x from which we consider the start of the phenomenon.
  • p : Precision.
             g(d)=Q*p Since the function never reaches 0 nor Q, we have to set an approximation for 0 or Q.
  • k : Efficiency.
             This parameter influences the length of the phenomenon.

Differential form:

Let the following be a Cauchy problem: y: x → y(x) a real function y' = b*y*(1-y/K) y(0) = p

The solution of this Cauchy problem is as below: y(x) = K/(1+(K/p – 1)*e^-bx)

Here is our logistic function. Yet, differential equations are not always time-related. Let x be a temporal function, and y be a x-related logistic function. In order to integrate y into a temporal ODE, we need to write it differently: dy/dx = by(x(t))(1 – y(x(t))/K) <=>( dy/dt)/(dx/dt) = by(x(t))(1 – y(x(t))/K)

And so: dy/dt = dx/dt * by(x(t))(1 – y(x(t))/K) If t → x(t) is a continuous real function, then: y(x(t)) = y(t) Finally, dy/dt = dx/dt * by(1 – y/K)

References: