Team:Uppsala/test

From 2013.igem.org

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<title>Uppsala iGEM 2013</title>
<title>Uppsala iGEM 2013</title>
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<div id="igem"><a href="https://2013.igem.org/Main_Page"><img class="igem" src="https://static.igem.org/mediawiki/2013/b/b8/Uppsala2013_Uppsala_IGEM_log_blue.png"></a></div>
<div id="igem"><a href="https://2013.igem.org/Main_Page"><img class="igem" src="https://static.igem.org/mediawiki/2013/b/b8/Uppsala2013_Uppsala_IGEM_log_blue.png"></a></div>
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<img class="slogan" src="https://static.igem.org/mediawiki/2013/a/ad/Uppsala2013_Header.png">
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                                                                 <li><a  
                                                                 <li><a  
href="https://2013.igem.org/Team:Uppsala/saffron">Saffron</a></li>
href="https://2013.igem.org/Team:Uppsala/saffron">Saffron</a></li>
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<li><a href="https://2013.igem.org/Team:Uppsala/astraxantin">Astaxanthin</a></li>
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<li><a href="https://2013.igem.org/Team:Uppsala/astaxanthin">Astaxanthin</a></li>
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<li><a href="https://2013.igem.org/Team:Uppsala/zeaxantin">Zeaxanthin</a></li>
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<li><a href="https://2013.igem.org/Team:Uppsala/zeaxanthin">Zeaxanthin</a></li>
</ul></li>
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<li><a href="https://2013.igem.org/Team:Uppsala/chromoproteins">Chromoproteins</a></li>
<li><a href="https://2013.igem.org/Team:Uppsala/chromoproteins">Chromoproteins</a></li>
<li><a href="https://2013.igem.org/Team:Uppsala/safety-experiment">Safety experiment</a></li>
<li><a href="https://2013.igem.org/Team:Uppsala/safety-experiment">Safety experiment</a></li>
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<li><a href="https://2013.igem.org/Team:Uppsala/result">Results</a></li>
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<li><a href="https://2013.igem.org/Team:Uppsala/results">Results</a></li>
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<li><a href="https://2013.igem.org/Team:Uppsala/carotenoid-group">Carotenoid group</a></li>
<li><a href="https://2013.igem.org/Team:Uppsala/carotenoid-group">Carotenoid group</a></li>
<li><a href="https://2013.igem.org/Team:Uppsala/chassi-group">Chassi group</a></li>
<li><a href="https://2013.igem.org/Team:Uppsala/chassi-group">Chassi group</a></li>
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                                                <li><a href="https://2013.igem.org/Team:Uppsala/advisors">Advisors</a></li>
</ul></li>
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<li><a href="https://2013.igem.org/Team:Uppsala/hp" id="list_type3"><img class="nav-text"      src="https://static.igem.org/mediawiki/2013/b/b8/Uppsala2013_HP.png"></a>
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<li><a href="https://2013.igem.org/Team:Uppsala/human-practice" id="list_type3"><img class="nav-text"      src="https://static.igem.org/mediawiki/2013/b/b8/Uppsala2013_HP.png"></a>
<ul>
<ul>
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<li><a href="https://2013.igem.org/Team:Uppsala/Yoghurtproducts">Yoghurt +</a></li>
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<li><a href="https://2013.igem.org/Team:Uppsala/yoghurt">Yoghurt +</a></li>
<li><a href="https://2013.igem.org/Team:Uppsala/synbioday">SynBioDay</a></li>
<li><a href="https://2013.igem.org/Team:Uppsala/synbioday">SynBioDay</a></li>
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<li><a href="https://2013.igem.org/Team:Uppsala/safety">Biosafety and ethics</a></li>
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<li><a href="https://2013.igem.org/Team:Uppsala/biosafety-and-ethics">Biosafety and ethics</a></li>
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<li><a href="https://2013.igem.org/Team:Uppsala/society">Public opinion </a></li>
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<li><a href="https://2013.igem.org/Team:Uppsala/public-opinion">Public opinion </a></li>
                                                 <li><a href="https://2013.igem.org/Team:Uppsala/Outreach">High school & media </a></li>
                                                 <li><a href="https://2013.igem.org/Team:Uppsala/Outreach">High school & media </a></li>
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<li><a href="https://2013.igem.org/Team:Uppsala/bioart">BioArt</a></li>
</ul></li>
</ul></li>
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<li><a href="https://2013.igem.org/Team:Uppsala/attribution" id="list_type4"><img class="nav-text" src="https://static.igem.org/mediawiki/2013/5/5d/Uppsala2013_Attributions.png"></a>
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<li><a href="https://2013.igem.org/Team:Uppsala/attribution" id="list_type4"><img class="nav-text" src="https://static.igem.org/mediawiki/2013/5/5d/Uppsala2013_Attributions.png"></a></li>  
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                                <ul>
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                                    <li><a href="https://2013.igem.org/Team:Uppsala/collaboration">Collaboration</a></li>
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                                </ul></li>  
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<li><a href="https://2013.igem.org/Team:Uppsala/notebook" id="list_type3"><img class="nav-text" src="https://static.igem.org/mediawiki/2013/3/36/Uppsala2013_Notebook.png"></a>
<li><a href="https://2013.igem.org/Team:Uppsala/notebook" id="list_type3"><img class="nav-text" src="https://static.igem.org/mediawiki/2013/3/36/Uppsala2013_Notebook.png"></a>
                                     <ul>
                                     <ul>
                                         <li><a href="https://2013.igem.org/Team:Uppsala/safety-form">Safety form</a></li>
                                         <li><a href="https://2013.igem.org/Team:Uppsala/safety-form">Safety form</a></li>
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                                        <li><a href="https://2013.igem.org/Team:Uppsala/protocols">Protocols</a></li>
                                     </ul></li>
                                     </ul></li>
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<div id="main_content">  
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        <h1> Metabolic Engineering </h1>
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<img src="https://static.igem.org/mediawiki/2013/7/75/1379092_10152032735758413_677462372_n.jpg" style="width:900px;">
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<div id="project-description">
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<h1>
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Making the world healthier with a new probiotic platform
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</h1>
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                <div id="text-box">
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<p class="project-text"> Malnutrition is today a major global problem that affects people both in affluent and developing countries. Even if you get the right amount of calories, if these do not contain sufficient amounts of micronutrients, like vitamins and minerals, serious illness and even death can be the result.
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<div id="chassi_text_top"> <p> We have aimed our project at producing food nutrients in bacteria. These nutrients normally exists in for example carrots, tomatoes, garlic, grapes and several other important food. By transferring genes from plants and fruits we can make our bacteria produce vital nutrients and commercially attractive supplements. We alter the metabolic pathways of our bacteria by introducing new genes or by modifying existing pathways. </p>
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The goal of our project is to alleviate this problem by applying synthetic biology to <a href="https://2013.igem.org/Team:Uppsala/probiotics">probiotic bacteria</a>. These bacteria are already a part of normal human diet and our goal is to modify them so that they enrich the nutritional content of the food they grow in.<br><br>
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<p> Organic materia produced by nature is one of our main sources of energy. For billions of years, nature has perfected its machinery. We get fuel from both fossilized organisms and renewable biomateria. All life on earth is dependent of getting the right amount of food and nutrition. As we become more and more people on earth, we need to optimize our techniques for food and nutritional production. This is where we can step in and alter natures machinery. </p>
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With our project, we will make the lactobacillus genus the <a href="https://2013.igem.org/Team:Uppsala/chassi"> new probiotic platform </a> for <a href="https://2013.igem.org/Team:Uppsala/metabolic-engineering"> metabolic engineering </a> of nutritional compounds. We will engineer probiotics to produce beta-carotene (provitamin), resveratrol (antioxidant), miraculin (sweetener) and saffron (taste).
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</div>
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<div id="shortcut_pic">  
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To exemplify what this combination of probiotics and metabolic engineering can accomplish we hope to use our modified bacteria to create nutritionally enriched yoghurt. We have also put great effort into addressing the <a href="https://2013.igem.org/Team:Uppsala/biosafety-and-ethics"> ethical and safety </a> issues that naturally follow when creating genetically modified food. As a part of this we organised a large event, <a href="https://2013.igem.org/Team:Uppsala/synbioday"> Uppsala SynBioDay </a>, with over 200 participants where these issues were discussed.
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<div id="chassi_pic_container_a">
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</p>
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<div id="metabolic_pic_lycopene"> <a href="https://2013.igem.org/Team:Uppsala/lycopene"><img class="metabolic_pic" src="https://static.igem.org/mediawiki/2013/3/39/Uppsala2013_Lycopene2.png" onmouseover="this.src='https://static.igem.org/mediawiki/2013/b/b4/Uppsala2013_LycopenePushed.png'" onmouseout="this.src='https://static.igem.org/mediawiki/2013/3/39/Uppsala2013_Lycopene2.png'"> </div>
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<div id="metabolic_pic_zeaxanthin"> <a href="https://2013.igem.org/Team:Uppsala/zeaxantin"><img class="metabolic_pic" src="https://static.igem.org/mediawiki/2013/0/0b/Uppsala2013_Zeaxantin2.png" onmousemove="this.src='https://static.igem.org/mediawiki/2013/0/07/Uppsala2013_Zeaxantin2Pushed.png'" onmouseout="this.src='https://static.igem.org/mediawiki/2013/0/0b/Uppsala2013_Zeaxantin2.png'"> </div>
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<div id="metabolic_pic_astaxanthin"><a href="https://2013.igem.org/Team:Uppsala/astraxantin"><img class="metabolic_pic" src="https://static.igem.org/mediawiki/2013/3/3a/Uppsala2013_Astaxanthin2.png" onmouseover="this.src='https://static.igem.org/mediawiki/2013/0/0d/Uppsala2013_Astaxanthin2Pushed.png'" onmouseout="this.src='https://static.igem.org/mediawiki/2013/3/3a/Uppsala2013_Astaxanthin2.png'"> </div>
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<div style="background-image:url('https://static.igem.org/mediawiki/2013/6/6c/Uppsala_cow_Upprop.png') o-repeat fixed center; background-size: 80% 80%; width: 100%; height: 200px;" ">
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<div id="chassi_pic_container_b">
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<div id="metabolic_pic_beta_carotene"><a href="https://2013.igem.org/Team:Uppsala/betacarotene"><img class="metabolic_pic" src="https://static.igem.org/mediawiki/2013/3/3c/Uppsala2013_beta-carotene2.png" onmouseover="this.src='https://static.igem.org/mediawiki/2013/0/04/Uppsala2013_beta-carotene2Pushed.png'" onmouseout="this.src='https://static.igem.org/mediawiki/2013/3/3c/Uppsala2013_beta-carotene2.png'"> </div>
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<div id="metabolic_pic_saffron"><a href="https://2013.igem.org/Team:Uppsala/saffron"><img class="metabolic_pic" src="https://static.igem.org/mediawiki/2013/7/7a/Uppsala2013_Saffron2.png" onmouseover="this.src='https://static.igem.org/mediawiki/2013/8/8f/Uppsala2013_Saffron2Pushed.png'"
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onmouseout="this.src='https://static.igem.org/mediawiki/2013/7/7a/Uppsala2013_Saffron2.png'"> </div>
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<div id="metabolic_pic_coumeric"><a href="https://2013.igem.org/Team:Uppsala/p-coumaric-acid"><img class="metabolic_pic" src="https://static.igem.org/mediawiki/2013/0/02/Uppsala2013_P-coumaric_acid2.png" onmouseover="this.src='https://static.igem.org/mediawiki/2013/4/4a/Uppsala2013_0P-coumaric_acid2Pushed.png'" onmouseout="this.src='https://static.igem.org/mediawiki/2013/0/02/Uppsala2013_P-coumaric_acid2.png'"> </div>
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<div id="metabolic_pic_resveratrol"><a href="https://2013.igem.org/Team:Uppsala/resveratrol"><img class="metabolic_pic" src="https://static.igem.org/mediawiki/2013/0/08/Uppsala2013_Resveratrol2.png" onmouseover="this.src='https://static.igem.org/mediawiki/2013/0/04/Uppsala2013_Resveratrol2Pushed.png'" onmouseout="this.src='https://static.igem.org/mediawiki/2013/0/08/Uppsala2013_Resveratrol2.png'"> </div>
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</div>
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</div> <!-- Closing div for shortcut_pic -->
 
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<img src="" style="width:80%;">
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      <div style="z-index: 1000;width: 300px; height: 50px; position: relative; top: 500x; left: 500px; border: 1px solid black;"><a href="" style="width: 100%; height: 100%;"></a></div>
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<div>
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<div id="grid-matrix">
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<div id="container_mini_pic">  
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<div id="grid-a">
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<div class="text_box_in_the_box" id="coumeric_div">
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  <a href="https://2013.igem.org/Team:Uppsala/project#project-anchor"><img class="top" src="https://static.igem.org/mediawiki/2013/a/a3/Uppsala2013_Background_new.png"></a>
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<a href="https://2013.igem.org/Team:Uppsala/p-coumaric-acid">
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<div id="substance_title"> <h3> P-coumaric acid </h3> </div>
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<div class="coumeric_pic"> <img class="metabolic_mini_pic" src="https://static.igem.org/mediawiki/2013/0/02/20130924122324%21Uppsala2013_P-coumaric_acid3.png"> </div>
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</a>
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<div id="substance_text"> <p> P-coumaric acid is an antioxidant that is produced from tyrosin by the enzyme Tyrosine ammonia lyase (TAL). This antioxidant has been shown to have many health benefits. For example studies have shown that it can reduce the risk of atherosclerosis and also reduce the risk of stomach cancer. P-coumaric acid can be found foods such as peanuts, garlic, wine and vinegar. </p>  
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<div id="grid-b">
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                        <a href="https://2013.igem.org/Team:Uppsala/project#vision-anchor"><img class="top" src="https://static.igem.org/mediawiki/2013/1/13/Uppsala2013_Vision.png"></a>
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</div>
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<div id="substance_plasmid"> <a href="https://2013.igem.org/Team:Uppsala/p-coumaric-acid#b1"> <img class="substance_plasmid" src="https://static.igem.org/mediawiki/2013/1/18/Uppsala2013_P-coumaric_plasmid.png"></a> </div>
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<div id="grid-c">
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                        <a href="https://2013.igem.org/Team:Uppsala/metabolic-engineering"><img class="top" src="https://static.igem.org/mediawiki/2013/4/4f/Uppsala2013_Metabolicengineering.png"></a>
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<div id="grid-d">
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                        <a href="https://2013.igem.org/Team:Uppsala/chassi"><img class="top" src="https://static.igem.org/mediawiki/2013/1/19/Uppsala2013_Chassi.png"></a>
</div>
</div>
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<div id="grid-e">
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                        <a href="https://2013.igem.org/Team:Uppsala/human-practice"><img class="top" src="https://static.igem.org/mediawiki/2013/d/de/Uppsala2013_HumanPractice.png"></a>
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<div id="grid-f">
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                <div class="text_box_in_the_box" id="resveratrol_div">  
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                        <a href="https://2013.igem.org/Team:Uppsala/results"><img class="top" src="https://static.igem.org/mediawiki/2013/a/a3/Uppsala2013_Achievements.png"></a>
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<a href="https://2013.igem.org/Team:Uppsala/resveratrol">
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<div id="substance_title"> <h3> Resveratrol </h3> </div>
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<div class="resveratrol_pic"> <img class="metabolic_mini_pic" src="https://static.igem.org/mediawiki/2013/b/bb/Uppsala2013_ResveratrolSymbol.png"> </div>
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<div id="substance_text"> <p>Resveratrol belongs to a group of molecules known as Phyloalexin which is used by many plants to battle infections of all sorts. Many studies have been done on resveratrol showing it has a wide range of beneficial properties ranging from skin cancer reduction to anti-inflamatory effects and antioxidant properties. Perhaps the most interesting property is that of life extension.</p>
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<div id="substance_plasmid"> <a href="https://2013.igem.org/Team:Uppsala/resveratrol#b1"> <img class="substance_plasmid" src="https://static.igem.org/mediawiki/2013/c/c5/Uppsala2013_Resveratrol_plasmid.png"></a> </div>
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</div>
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<div class="text_box_in_the_box" id="lycopene_div">
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<div id="sidebar">
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<a href="https://2013.igem.org/Team:Uppsala/lycopene">
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<div id="substance_title"> <h3> Lycopene </h3> </div>
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<div class="lycopene_pic"> <img class="metabolic_mini_pic" src="https://static.igem.org/mediawiki/2013/8/8f/Uppsala2013_LycopeneSymbol.png"> </div>
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</a>
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<div id="substance_text"> <p> Lycopene is a carotenoid that primarily derives from the xanthophyll group. The precursor responsible for lycopene production is phytoene, when present together with the enzyme CrtE a catalytic reaction takes place and lycopene is produced. Lycopene is an antioxidant that can be found in both vegetables and fruits, it is mostly known for its characteristic red color in tomatoes.  </p>  
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<div id="fb-feed">
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<div id="substance_plasmid"> <a href="https://2013.igem.org/Team:Uppsala/lycopene#b1"> <img class="substance_plasmid" src="https://static.igem.org/mediawiki/2013/d/d4/Uppsala2013_Lycopene-plasmid.png"></a> </div>
 
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                <div class="text_box_in_the_box" id="beta_carotene_div">
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<iframe src="http://www.facebook.com/plugins/likebox.php?href=http://www.facebook.com/UppsalaIgem?fref=ts&width=292&colorscheme=light&show_fa
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<a href="https://2013.igem.org/Team:Uppsala/betacarotene">
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ces=false&amp;border_color&amp;stream=true&amp;header=false&amp;height=475" scrolling="no" frameborder="0" style="border:none;
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<div id="substance_title"> <h3> β-carotene </h3> </div>
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overflow:hidden; width:310px; height:475px;" allowTransparency="true"></iframe>
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<div class="beta_carotene_pic"> <img class="metabolic_mini_pic" src="https://static.igem.org/mediawiki/2013/0/00/Uppsala2013_beta-caroteneSymbol.png"> </div>
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</a>
 
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        <div id="substance_text"> <p> β-carotene is a precursor of substances such as Vitamin A, zeaxanthine and asthaxanthine. β-carotene is a derive from Lycopene and is commonly known for its characteristic orange color, it is found in fruits and vegetables. Vitamin A which is a derive from β-carotene has important health aspects for our skin, different membranes and most commonly known our eyes. </p>
 
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<div id="substance_plasmid"> <a href="https://2013.igem.org/Team:Uppsala/betacarotene#b1"><img class="substance_plasmid" src="https://static.igem.org/mediawiki/2013/0/02/Uppsala2013_Beta-caroten_photoshop_f%C3%A4rdig_%281%29.png"></a> </div>
 
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<div id="twitter-feed">
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                <div class="text_box_in_the_box" id="astaxanthin_div">
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<a class="twitter-timeline" data-dnt="true" href="https://twitter.com/igemuppsala" data-widget-id="352909282024505345">Tweets av @igemuppsala</a>
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<a href="https://2013.igem.org/Team:Uppsala/astraxantin">
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<script>!function(d,s,id){var js,fjs=d.getElementsByTagName(s)[0],p=/^http:/.test(d.location)?'http':'https';if(!d.getElementById(id)){js=d.createElement(s);js.id=id;js.src=p+"://platform.twitter.com/widgets.js";fjs.parentNode.insertBefore(js,fjs);}}(document,"script","twitter-wjs");</script>
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<div id="substance_title"> <h3> Astaxanthin </h3> </div>
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<div class="astaxanthin_pic"> <img class="metabolic_mini_pic" src="https://static.igem.org/mediawiki/2013/d/d8/Uppsala2013_AstaxanthinSymbol.png"> </div>
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</a>
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<div id="substance_text"> <p> Astaxanthin is a carotenoid pigment that derives from the xanthophyll group and is most known for giving the red color of salmon, lobster and shrimp. Astaxanthin is a very strong antioxidant and is produced using the microalgae Haematococcus or synthetically. The substance costs around 2500 US dollars per kg and is often used in fishfarming to give salmon its red color.</p>  
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<div id="substance_plasmid"> <a href="https://2013.igem.org/Team:Uppsala/astraxantin#b1"> <img class="substance_plasmid" src="https://static.igem.org/mediawiki/2013/5/50/Uppsala2013_Astaxanthin_plasmid.png"> </a> </div>
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<div id="substance_title"> <h3> Zeaxanthin </h3> </div>
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<div id="substance_text"> Zeaxanthin is a yellow carotenoid derived from the precursor ß-carotene by the enzyme ”Beta-carotene hydroxylase”. Zeaxanthin acts as an antioxidant and can be found in for example peppers, yolk and maize. According to studies zeaxanthin has positive effects on both undamaged and impaired vision and it may prevent age-related macular degeneration (AMD).
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<td class="centerThis"><img class="sponsors" src="https://static.igem.org/mediawiki/2013/a/a4/Uppsala_Clc.png"></td>
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<td><img class="sponsors" src="https://static.igem.org/mediawiki/2013/5/55/Uppsala_TekNat.png"></td><td><img class="sponsors" src="https://static.igem.org/mediawiki/2013/1/14/Uppsala_Analytik_Jena.png"></td></tr>
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<tr><td class="centerThis"><img class="sponsors" src="https://static.igem.org/mediawiki/2013/6/69/Uppsala_UU_logo.png"></td><td><img class="sponsors" src="https://static.igem.org/mediawiki/2013/9/9a/Uppsala_Microsynth.png"></td><td><img class="sponsors" src="https://static.igem.org/mediawiki/2013/b/ba/Vinnova.png"></td>
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<div id="substance_text"> <p>Saffron is the most expensive spice in the world. It is extracted from the stigmata of Crocus Sativus. The flower can be cultivated in the Mediterranean and Middle East area. The spice is a combination of over 150 different compounds, but the main components are picrocrocin (taste), safranal (aroma) and crocin (colour). These components are all derivatives of zeaxanthin.  </p>
 
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Latest revision as of 15:12, 27 October 2013

Making the world healthier with a new probiotic platform

Malnutrition is today a major global problem that affects people both in affluent and developing countries. Even if you get the right amount of calories, if these do not contain sufficient amounts of micronutrients, like vitamins and minerals, serious illness and even death can be the result. The goal of our project is to alleviate this problem by applying synthetic biology to probiotic bacteria. These bacteria are already a part of normal human diet and our goal is to modify them so that they enrich the nutritional content of the food they grow in.

With our project, we will make the lactobacillus genus the new probiotic platform for metabolic engineering of nutritional compounds. We will engineer probiotics to produce beta-carotene (provitamin), resveratrol (antioxidant), miraculin (sweetener) and saffron (taste). To exemplify what this combination of probiotics and metabolic engineering can accomplish we hope to use our modified bacteria to create nutritionally enriched yoghurt. We have also put great effort into addressing the ethical and safety issues that naturally follow when creating genetically modified food. As a part of this we organised a large event, Uppsala SynBioDay , with over 200 participants where these issues were discussed.

Retrieved from "http://2013.igem.org/Team:Uppsala/test"