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Team:Calgary/Sandbox/Project/TALEs
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<h1>TALEs</h1> | <h1>TALEs</h1> | ||
| - | <p><b>T</b>ranscription <b>A</b>ctivator <b>L</b>ike <b>E</b> | + | <p><b>T</b>ranscription <b>A</b>ctivator-<b>L</b>ike <b>E</b>ffectors (TALEs) are naturally occurring proteins that bind to DNA. These proteins are found in <i>Xanthomonas</i> species, a plant pathogen, and originally serve as a pathogenic factor. However recently we have discovered the modular property of TALEs which make them particularly amenable to genetic engineering and customization.</p> |
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| + | <p> We have engineered a TALE that binds to the shiga toxin II gene, <i>Stx2</i> in <i> E. coli </i> and other entero-haemorrhagic bacteria. </p> | ||
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| + | <p> To learn more about the design consideration of the TALEs click here <INSERT LINK>. </p> | ||
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| + | <p> For characterization data on <i>E. coli </i> click here <INSERT LINK>. </p> | ||
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Latest revision as of 21:21, 8 September 2013
TALEs
Transcription Activator-Like Effectors (TALEs) are naturally occurring proteins that bind to DNA. These proteins are found in Xanthomonas species, a plant pathogen, and originally serve as a pathogenic factor. However recently we have discovered the modular property of TALEs which make them particularly amenable to genetic engineering and customization.
We have engineered a TALE that binds to the shiga toxin II gene, Stx2 in E. coli and other entero-haemorrhagic bacteria.
To learn more about the design consideration of the TALEs click here
For characterization data on E. coli click here
