Team:INSA Toulouse

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       <h1 class="h1project">Project</h1>
       <h1 class="h1project">Project</h1>
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       <p>Since the beginning of Synthetic Biology, people aimed to transpose electronic devices into genetic constructions. In recent publications (<a href="http://www.ncbi.nlm.nih.gov/pubmed/23396014" style="color: #5a6060">Siuti and al. 2013</a>, <a href="http://www.sciencemag.org/content/340/6132/599.abstract" style="color: #5a6060">Bonnet and al. 2013</a>), a new design of one-way logical gates using Serine recombinases were described allowing to avoid reversibility of recombination and creating strong and robust genetic logical gates (AND, XOR, OR).  
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       <p>One major goal of Synthetic Biology is the transposition of electronic devices such as logic gates into genetic modules capables of complex, autonomous decisions. Very recent publications described highly original logic gates utilizing serine recombinases, avoiding reversibility of the genetic switch and thus creating strong and robust genetic logical gates (AND, XOR, OR). <br> The <i>E. calculus</i> project exemplifies these genetic modules by creating a binary full-adder using AND and XOR gates. Our envisionned design could theoritically perform n-bits counting with a carry. Our project also aimed at validating original properties of these new genetic switches: irreversibility and accurate genetic transmission of the logic gate switched state to the cell'offspring.</p>
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The <i>E.calculus</i> project consists in creating a n-bits full-adder using those kinds of logical gates, which should be able to execute a 2 bits counting and also transmit any carry on the next step of the counting.</p>
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<div class="buttoncadre1"> <a href="https://2013.igem.org/Team:INSA_Toulouse/contenu/project/overview" style="color:grey;"><p> VIEW MORE</p></a>
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    <p><a href="https://2013.igem.org/Team:INSA_Toulouse/contenu/project/overview" style="color:white; text-decoration:none; weight:bold;">VIEW MORE</a></p>
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              <div class="imgnew"><a href="https://2013.igem.org/Team:INSA_Toulouse/contenu/extras/achievements"><img style="width:70px;" src="https://static.igem.org/mediawiki/2013/a/a8/Three-olympic-medals.png"/></a></div>
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              <div class="textnew"><a href="https://2013.igem.org/Team:INSA_Toulouse/contenu/extras/achievements" style="color:grey;"><p>Check out our ACHIEVEMENTS page!! Watch out for this!!</p></a></div>
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               <div class="textnew"><p>AND1 and XOR1 gates switched!!!!</p><a href="https://2013.igem.org/Team:INSA_Toulouse/contenu/lab_practice/results" style="color:grey;">View more</a></div>
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               <div class="textnew"><a href="https://2013.igem.org/Team:INSA_Toulouse/contenu/lab_practice/results" style="color:grey;"><p>AND1 and XOR1 gates switched!!!!</p></a></div>
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Latest revision as of 01:53, 5 October 2013

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Project

One major goal of Synthetic Biology is the transposition of electronic devices such as logic gates into genetic modules capables of complex, autonomous decisions. Very recent publications described highly original logic gates utilizing serine recombinases, avoiding reversibility of the genetic switch and thus creating strong and robust genetic logical gates (AND, XOR, OR).
The E. calculus project exemplifies these genetic modules by creating a binary full-adder using AND and XOR gates. Our envisionned design could theoritically perform n-bits counting with a carry. Our project also aimed at validating original properties of these new genetic switches: irreversibility and accurate genetic transmission of the logic gate switched state to the cell'offspring.