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Team:Calgary/Sandbox/Project/TALEs
From 2013.igem.org
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| - | <p><b>T</b>ranscription <b>A</b>ctivator <b>L</b>ike <b>E</b>ffector (TALE)s are naturally occurring proteins in <i>Xanthomonas</i> bacteria | + | <p><b>T</b>ranscription <b>A</b>ctivator <b>L</b>ike <b>E</b>ffector (TALE)s are naturally occurring proteins that bind to DNA. These proteins are found in <i>Xanthomonas</i> bacteria, a plant pathogen, and originally serve as a pathogenic factor. However recently we have discovered the modular property of TALEs which make them particularly amenable to genetic engineering and customization. </p> |
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| + | <p> We have engineered a TALE that binds to the shiga toxin II gene in <i> E. coli </i> and other enterohemoraggic bacteria. </p> | ||
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Revision as of 23:43, 3 September 2013
TALEs
Transcription Activator Like Effector (TALE)s are naturally occurring proteins that bind to DNA. These proteins are found in Xanthomonas bacteria, a plant pathogen, and originally serve as a pathogenic factor. However recently we have discovered the modular property of TALEs which make them particularly amenable to genetic engineering and customization.
We have engineered a TALE that binds to the shiga toxin II gene in E. coli and other enterohemoraggic bacteria.
