Team:Evry/Metabolism model

From 2013.igem.org

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<h1>Flux model</h1>
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<h1>Flux modeling</h1>
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In this part of our modeling work we focus on genome scale analysis of the enterobactin production pathway. A major concern about our system is its non-orthogonality with the natural metabolic network of the cells : E.Coli already possesses the genes for producing enterobactins. Therefore we wanted to assess the possible interactions between our system and the bacterial metabolism.
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<h1>Observations</h1>
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This model stems from the following observations :
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<li>Enterobactin production pathway is a metabolic process;</li>
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<li>Any of the involved metabolites may limit the rate of the reactions.</li>
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To keep in mind the figure 1 presents the reactions composing the enterobacting production pathway.
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<img src="https://static.igem.org/mediawiki/2013/3/3b/EntBS.png" alt="enterobactin production pathway" />
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As we can see there are
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<img src="https://static.igem.org/mediawiki/2013/7/76/Metabolic_network_entero_full.png" alt="Enterobactin metabolic network"/>
<img src="https://static.igem.org/mediawiki/2013/7/76/Metabolic_network_entero_full.png" alt="Enterobactin metabolic network"/>

Revision as of 23:02, 4 October 2013

Iron coli project

Flux modeling

In this part of our modeling work we focus on genome scale analysis of the enterobactin production pathway. A major concern about our system is its non-orthogonality with the natural metabolic network of the cells : E.Coli already possesses the genes for producing enterobactins. Therefore we wanted to assess the possible interactions between our system and the bacterial metabolism.

Observations

This model stems from the following observations :
  • Enterobactin production pathway is a metabolic process;
  • Any of the involved metabolites may limit the rate of the reactions.
To keep in mind the figure 1 presents the reactions composing the enterobacting production pathway. enterobactin production pathway As we can see there are Enterobactin metabolic network

Overview

Assumptions

Model Description

Results

Conclusion

References:

Retrieved from "http://2013.igem.org/Team:Evry/Metabolism_model"