Team:Evry/ent prod

From 2013.igem.org

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In order to determine our <b><span style="color:#bb8900">Iron</span><span style="color:#7B0000"> Coli</span></b>'s enterobactin production rate, we modelize the different systems uses in our project: the iron sensor, the inverter system and the chelator system.We then divided this model in 3 differents parts.<br/>
In order to determine our <b><span style="color:#bb8900">Iron</span><span style="color:#7B0000"> Coli</span></b>'s enterobactin production rate, we modelize the different systems uses in our project: the iron sensor, the inverter system and the chelator system.We then divided this model in 3 differents parts.<br/>
The first part focuses on the synthetic <a href="https://2013.igem.org/Team:Evry/Sensor">sensing system</a>, the second on our <a href="https://2013.igem.org/Team:Evry/Inverter">inverter system</a> our team implemented in the bacteria. The last part intagrate those previous parts with the chemical reactions leading to the enterobactin production.
The first part focuses on the synthetic <a href="https://2013.igem.org/Team:Evry/Sensor">sensing system</a>, the second on our <a href="https://2013.igem.org/Team:Evry/Inverter">inverter system</a> our team implemented in the bacteria. The last part intagrate those previous parts with the chemical reactions leading to the enterobactin production.
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<h2>Observations</h2>
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<h2>Sensor model</h2>
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We first modeled the iron absorption of a hemochromatosic patient using ODEs.
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<h2>Goals</h2>
 
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We wanted to build a generic duodenal iron absorption model so that:
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<a href="https://2013.igem.org/Team:Evry/Modelmeta1">Here is the link to the sensor model</a>.
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<li>We can have a realistic model of iron absorption: <em>"How iron is absorbed in an healthy person and in a sick patient ? </em></li>
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<li>We can know how our first strategy of treatment would work: <em>"Is it possible to chelate a significant amount of iron with a flush strategy?"</em></li>
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<h2>Materials and Methods</h2>
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<h2>Inverter model</h2>
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We then used the disease model as a base to develop our flush treatment model. It aims to answer the following question:<br/>
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<em>"Is it possible to chelate a significant amount of iron with a flush strategy?"</em>
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<h3>Assumptions</h3>
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<p>With use the same assumptions as in the previous model apply:
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<h3>Model</h3>
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<p>We use Ordinary Differential Equation to modelize the duodenum and the potentiel impact of our flush strategy treatment:
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<h2>Results</h2>
 
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<a href="https://2013.igem.org/Team:Evry/Modelmeta3">Here is the link to the inverter model</a>.
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<h2>Enterobactin production model</h2>
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<h2>Conclusion</h2>
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<h2>Models and scripts</h2>
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We then used the disease model as a base to develop our flush treatment model. It aims to answer the following question:<br/>
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<em>"Is it possible to chelate a significant amount of iron with a flush strategy?"</em>
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<a href="https://2013.igem.org/Team:Evry/Modelmeta3">Here is the link to the enterobactin production model</a>.
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Revision as of 02:33, 29 October 2013

Iron coli project

Enterobactin production model overview

Introduction

Ent

In order to determine our Iron Coli's enterobactin production rate, we modelize the different systems uses in our project: the iron sensor, the inverter system and the chelator system.We then divided this model in 3 differents parts.
The first part focuses on the synthetic sensing system, the second on our inverter system our team implemented in the bacteria. The last part intagrate those previous parts with the chemical reactions leading to the enterobactin production.

Sensor model

We first modeled the iron absorption of a hemochromatosic patient using ODEs.

Here is the link to the sensor model.

Inverter model

We then used the disease model as a base to develop our flush treatment model. It aims to answer the following question:
"Is it possible to chelate a significant amount of iron with a flush strategy?"

Here is the link to the inverter model.

Enterobactin production model

We then used the disease model as a base to develop our flush treatment model. It aims to answer the following question:
"Is it possible to chelate a significant amount of iron with a flush strategy?"

Here is the link to the enterobactin production model.

Retrieved from "http://2013.igem.org/Team:Evry/ent_prod"