Team:NJU China

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NJU China TeamLogo.pngBiomissile Site-specific drug delivery has always been a challenge in drug treatment. It is acknowledged that a new system needs to be developed in order to overcome the poor targeting, low effectiveness and low safety of present ones.
Microvesicles (MV) are lipid bilayer vesicles which are naturally secreted by almost every types of cells, playing a role in transportation of mRNA, miRNA, and proteins between cells. We are trying to construct a system which employs the freely movable MV as a vehicle to achieve site-specific drug delivery.

By transfecting recombinant plasmids into the human embryonic kidney cell (293T cell) which can produce large amounts of microvesicles, we are hoping to add targeting protein onto the surface of the MV to endow it with ability of site-specific recognition in order to realize the site-specificity.

siRNAs are known to play a significant role in RNA interference by degrading targeted RNA. Similarly, by transfecting the 293T cells with siRNA plasmids, we enable them to express anti-viral siRNAs which can be encapsulated into the MVs.

Our modified MVs are just like the missiles, which can destroy viral RNA and target specially to viral infected cells. So we call it “Biomissile”.

NJU China Team.JPG
Team NJU_China


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