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Team:Paris Saclay/Notebook/April/20
From 2013.igem.org
Notebook : April 20
Week end Brainstorming : 20&21 April 2013
People there : Instructors and advisors : Sylvie, Philippe, Nguyen, Solenne Students : Pierre-Louis, Gabriel, Zhou, Nima, Andy, Damir, Kevin, Jean-Rémy, Xavier, Caroline, Anaïs, Eric, Abdou.
Saturday 20th April :
1. Presentation of the simulation’s software of Damir
This is a htlm page that Damir did to follow any biological systems. This simple software can be use by everybody if they know the different constants of their system. (adresse ip) - Very good idea, we can develop it at the same time that the scientific project - Look if others software were done by igem teams - Find constants in literacy - Find people to help Damir
2. Proposition of projects
a) Caroline’s Project : Seine’s depollution
Problematic: PCBs are toxic, ecotoxic, carcinogenic and presents in the Seine in sediments.
The idea: create a biological system that can detect and degrade PCBs
Others iGEM team worked on it : Clemson 2012, Lethbridge 2008 Bielfield 2012
Questions:
- What chassis ?
- What genes and enzymes ? burkoderia, pseudomonas, http://www.ncbi.nlm.nih.gov/pubmed/23529656
- Can it possible to do ? Not to hard ? there a lot a genes and enzymes to combine
- Kind of action of the PCBs ?
- Safety : how to limit the spreading of the bacteria? Gemote ?
Pros and cons :
| + | - |
|---|---|
|
Seine = our environment to save |
Natural bacteria did it, why do it with E.Coli ? |
|
Burkoderia Xenovorans : one way, 2 gens : easier |
Can it work ? |
|
Complete subject : chemistrie, biology, ethics … |
PCBs are in sediments, how to degrade it ? |
Contacting ideas : Mr. Dubow to visit a water treatment plant
http://www.futura-sciences.com/fr/news/t/developpement-durable-1/d/pcb-la-frnce-contaminee_31534
http://www.futura-sciences.com/fr/news/t/developpement-durable-1/d/pollution-fluviale-au-pcb-une-etude-sonne-lalerte_15709
b) Nima’s Project
Problematic: Cambridge 2007 BOL : Bacteria Online https://2007.igem.org/wiki/index.php/Project
Idea : Make a analogy between internet and synbiology : intern and extern communication. Creation of an amplification system of flux with a binary system
Questions: - Degradation of the signal
- Order of the signals
- Storage of the signal
- How to restart the signal ?
Pros and Cons :
| + | - |
|---|---|
|
Interristing subject and original |
utility ? |
c) N Guyen’s proposition : detection of Cs
Questions :
- Receptors known ?
- Reaction that can be developed ?
Pros and cons :
| + | - |
|---|---|
|
Environment project : attractiv |
Tc and LA : radioactive forms |
|
concrete utility |
Can we make the difference between Cs and radioactive Cs ? |
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