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Team:Evry/Modeltr1
From 2013.igem.org
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| - | + | 60% of iron absorption takes place in the duodenum, the last 40% in the jejunum.Duodenum is located on the upper intestines, just after the stomach, and is usually 300mm long. Naturaly, the middle is the duodenum. | |
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| - | A healthy person absorbed 10% of the iron uptake of a day, while a sick person could absorb between 50% and 100% of the iron uptake in one day ([1]). | + | A healthy person absorbed 10% of the iron uptake of a day (2 mg), while a sick person could absorb between 50% and 100% of the iron uptake in one day ([1]). |
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<h2>Goals</h2> | <h2>Goals</h2> | ||
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| - | This model is the | + | This model is the first step for <a href="https://2013.igem.org/Team:Evry/Modeltr2">a sick person with treatment model</a> . So, we want to have a realistic base for <a href="https://2013.igem.org/Team:Evry/Modeltr2">the final model</a>. |
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Revision as of 15:10, 23 October 2013
Disease model
Introduction
At the beginning of the project, we must explore iron metabolism of a human. This model is the result of this exploration. So, we make a model of a healthy person.
Observations
60% of iron absorption takes place in the duodenum, the last 40% in the jejunum.Duodenum is located on the upper intestines, just after the stomach, and is usually 300mm long. Naturaly, the middle is the duodenum.
Figure 1 : Overview of the iron regulation system in human body.
A healthy person absorbed 10% of the iron uptake of a day (2 mg), while a sick person could absorb between 50% and 100% of the iron uptake in one day ([1]).
Goals
This model is the first step for a sick person with treatment model . So, we want to have a realistic base for the final model.
Assumptions
- Constant iron flow
- Homogeneous fluid
- The patient ingests 20mg of iron per day (Guideline Daily Amounts)
Materials and methods
Results
Figure 1 : Iron in the middle and absorbed in the duodenum of a Healthy person.
Figure 2 : Iron in the middle and absorbed in the duodenum of a sick person.
Conclusion
Models and scripts
References:
- Physiol Rev 93: 1721–1741, 2013 doi:10.1152/physrev.00008.2013 - Tomas Ganz "SYSTEMIC IRON HOMEOSTASIS"
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