Team:Evry/Protein Chelator

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<h2 id="FbpA">An alternative iron chelator</h2>
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<p>At the Regional Jamboree, we discussed with <a ref="https://2013.igem.org/Team:Edinburgh" target=‘_blank'>Edinburgh team</a> which also work on iron chelation but with another chelator: the ferric ion-binding protein A (FbpA). <br/>
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This protein from <i>Neisseria gonorrhoeae</i> is able to chelate various ion in solution as Fe<sup><small>3+</sup></small>
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, Ti<sup><small>4+</sup></small>,Cu<sup><small>2+</sup></small>, Zr<sup><small>4+</sup></small>(Zirconium ion)
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or Hf<sup><small>4+</sup></small> (Hafnium ion).</br>
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Its affinity for ferrous iron is 10<sup><small>18</sup></small>, less than our enterobactins system, but it remains a good alternative for our treatment.</p>
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Latest revision as of 22:47, 28 October 2013

Iron coli project

An alternative iron chelator

At the Regional Jamboree, we discussed with Edinburgh team which also work on iron chelation but with another chelator: the ferric ion-binding protein A (FbpA).
This protein from Neisseria gonorrhoeae is able to chelate various ion in solution as Fe3+ , Ti4+,Cu2+, Zr4+(Zirconium ion) or Hf4+ (Hafnium ion).
Its affinity for ferrous iron is 1018, less than our enterobactins system, but it remains a good alternative for our treatment.

References:

  • Alexeev, D., Zhu, H., Guo, M., Zhong, W., Hunter, D., Yang, W., Campopiano, D. and Sadler, P. (2003) A novel protein-mineral interface. Nature Structural Biology. 10. 297-302.
  • Ferreiros, C., Criado, M. and Gomez, J. (1999) The Neisserial 37kDa ferric binding protein (FbpA). Comparative Biochemistry and Physiology Part B. 123. 1-7.

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