Enterobactin production model overview

Introduction

In order to determine our Iron Coli's enterobactin production rate, we modelize the different systems uses in our project: the iron sensor, the inverter system and the chelator system.We then divided this model in 3 differents parts.
The first part focuses on the synthetic sensing system, the second on our inverter system our team implemented in the bacteria. The last part intagrate those previous parts with the chemical reactions leading to the enterobactin production.

Observations

Goals

We wanted to build a generic duodenal iron absorption model so that:

• We can have a realistic model of iron absorption: "How iron is absorbed in an healthy person and in a sick patient ?
• We can know how our first strategy of treatment would work: "Is it possible to chelate a significant amount of iron with a flush strategy?"

Materials and Methods

Assumptions

With use the same assumptions as in the previous model apply:

Model

We use Ordinary Differential Equation to modelize the duodenum and the potentiel impact of our flush strategy treatment:

Results

Conclusion

Models and scripts