Team:ETH Zurich/Modeling/Analytical Approximations

From 2013.igem.org

(Difference between revisions)
Line 3: Line 3:
<h1><b>Steady State AHL Gradient Approximation</b></h1>
<h1><b>Steady State AHL Gradient Approximation</b></h1>
-
In the reaction-diffusion model we have formalized the gradient establishment and we solved the resulting partial differential equation numerically. Now, the aim is to derive a suitable analytical approximation.  
+
<p align = "justify">In the reaction-diffusion model we have formalized the gradient establishment and we solved the resulting partial differential equation numerically. Now, the aim is to derive a suitable analytical approximation. </p>
<h1> Kolmogorov-Petrovsky-Piskounov Equation </h1>
<h1> Kolmogorov-Petrovsky-Piskounov Equation </h1>
-
A reaction–diffusion equation concerning the concentration of a single molecule in one spatial dimension is known as the Kolmogorov-Petrovsky-Piskounov Equation. In our case,  the equation for AHL has the following general structure:
+
<p align = "justify">A reaction–diffusion equation concerning the concentration of a single molecule in one spatial dimension is known as the Kolmogorov-Petrovsky-Piskounov Equation. In our case,  the equation for AHL has the following general structure:</p>
\begin{align}
\begin{align}
Line 12: Line 12:
\end{align}
\end{align}
-
And a less general form, as derived for the reaction-diffusion model for AHL:
+
<p align = "justify">And a less general form, as derived for the reaction-diffusion model for AHL:</p>
\begin{align}
\begin{align}
\frac{\partial AHL}{\partial t} = C_{agar} \cdot D_{AHL} \frac{\partial^2 AHL}{\partial x^2} +  DF \cdot (\alpha_{AHL} \cdot [LuxI]-d_{AHL,i} \cdot [AHL])  - d_{AHL,e} \cdot [AHL]
\frac{\partial AHL}{\partial t} = C_{agar} \cdot D_{AHL} \frac{\partial^2 AHL}{\partial x^2} +  DF \cdot (\alpha_{AHL} \cdot [LuxI]-d_{AHL,i} \cdot [AHL])  - d_{AHL,e} \cdot [AHL]
\end{align}
\end{align}
 +
 +
<p align = "justify"> For the analytical approximation of the AHL gradient in one dimension, we consider the boundary condition that the concentration at the reservoir (located at z = 0) stays constant:
 +
<br clear="all"/>
<br clear="all"/>
{{:Team:ETH_Zurich/templates/footer}}
{{:Team:ETH_Zurich/templates/footer}}

Revision as of 20:48, 24 October 2013

Header2.png
80px-Eth igem logo.png

Steady State AHL Gradient Approximation

In the reaction-diffusion model we have formalized the gradient establishment and we solved the resulting partial differential equation numerically. Now, the aim is to derive a suitable analytical approximation.

Kolmogorov-Petrovsky-Piskounov Equation

A reaction–diffusion equation concerning the concentration of a single molecule in one spatial dimension is known as the Kolmogorov-Petrovsky-Piskounov Equation. In our case, the equation for AHL has the following general structure:

\begin{align} \frac{\partial AHL(x,t)}{\partial t} = Diff(AHL(x,t),x) + R(AHL(x,t)) \end{align}

And a less general form, as derived for the reaction-diffusion model for AHL:

\begin{align} \frac{\partial AHL}{\partial t} = C_{agar} \cdot D_{AHL} \frac{\partial^2 AHL}{\partial x^2} + DF \cdot (\alpha_{AHL} \cdot [LuxI]-d_{AHL,i} \cdot [AHL]) - d_{AHL,e} \cdot [AHL] \end{align}

For the analytical approximation of the AHL gradient in one dimension, we consider the boundary condition that the concentration at the reservoir (located at z = 0) stays constant:
</div>