Team:Marburg

From 2013.igem.org

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The iGEM Marburg proudly presents: PHAECTORY
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{{:Team:Marburg/Template:ContentStart}}The use of proteins in medical treatment and diagnosis is steadily increasing. Many of these proteins (e.g. '''antibodies''') have a complex biological structure, which complicates their production. Also, these proteins need to be highly pure. Therefore, a major challenge is the development of systems that produce complex proteins with high purity - '''best at low costs'''!
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The sunlight-driven microalgae ''[[Team:Marburg/Project:Ptricornutum|Phaeodactylum tricornutum]]'' has been used for the production of complex proteins. A major '''[[Team:Marburg/Project:Challenge|advantage]]''' of the algae is its ability to secrete proteins directly into the medium. This feature would greatly simplify purification of recombinant proteins, and lower production costs! Here we take advantage of the excellent secretion abilities of ''P. tricornutum'', and make this organism accessible to synthetic biology and the iGEM competition ([https://2013.igem.org/Team:Marburg/Project PHAECTORY]).
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|You can write a background of your team here.  Give us a background of your team, the members, etc.  Or tell us more about something of your choosing.
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''Tell us more about your project. Give us background.  Use this as the abstract of your project. Be descriptive but concise (1-2 paragraphs)''
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|[[Image:Marburg_team.png|right|frame|Your team picture]]
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|align="center"|[[Team:Marburg | Team Marburg]]
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<!--- The Mission, Experiments --->
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Furthermore, we used a light-inducible promoter which we have characterized quantitatively in order to control protein expression in PHAECTORY ([https://2013.igem.org/Team:Marburg/Project:lightcontrol Light control]). Also, we introduced a transferable element to the registry, which allows autonomous targeting of proteins to the inner surface of cell membranes ([https://2013.igem.org/Team:Marburg/Project:RFP Improve a Brick]). We hope you enjoy reading about our project!
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!align="center"|[[Team:Marburg|Home]]
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!align="center"|[[Team:Marburg/Team|Team]]
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!align="center"|[https://igem.org/Team.cgi?year=2013&team_name=Marburg Official Team Profile]
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!align="center"|[[Team:Marburg/Project|Project]]
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!align="center"|[[Team:Marburg/Parts|Parts Submitted to the Registry]]
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!align="center"|[[Team:Marburg/Modeling|Modeling]]
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!align="center"|[[Team:Marburg/Safety|Safety]]
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!align="center"|[[Team:Marburg/Attributions|Attributions]]
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<div class="home">
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<div class="home_youtube">
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<center><b><a href="http://www.youtube.com/embed/mN9WnJ14-Yo" target="_blank">Video Introduction</a></b></center>
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<a href="http://www.youtube.com/embed/mN9WnJ14-Yo" target="_blank">
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<img src="https://static.igem.org/mediawiki/2013/3/31/Mr-igem-youtube.png" alt="YouTube Video" />
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<center><b><a href="https://2013.igem.org/Team:Marburg/Human_Practice">Human Practice</a></b></center>
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            <a href="https://2013.igem.org/Team:Marburg/Human_Practice:DayofSynthBiology">
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            <img src="https://static.igem.org/mediawiki/2013/d/d8/Mr_home_day_of_syn.png" /></a>
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            <a href="https://2013.igem.org/Team:Marburg/Human_Practice:Hessentag">
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            <img src="https://static.igem.org/mediawiki/2013/1/17/Mr_home_hessentag.png" alt="hessentag"/></a>
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            <a href="https://2013.igem.org/Team:Marburg/Human_Practice:Students">
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            <img src="https://static.igem.org/mediawiki/2013/5/53/Mr_home_school.png" /></a>
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            <a href="https://2013.igem.org/Team:Marburg/Human_Practice/Conferences:BioTech2020plus">
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            <img src="https://static.igem.org/mediawiki/2013/f/f5/MR_cycle_biotech.png" /></a>
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            <a href="https://2013.igem.org/Team:Marburg/Human_Practice:Debate">
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<a href="https://2013.igem.org/Team:Marburg/Human_Practice:Hessentag">
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            <img src="https://static.igem.org/mediawiki/2013/1/17/Mr_home_hessentag.png" alt="hessentag"/></a>
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<br /><br />
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<h2>Our Sponsors</h2><br />
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<img src="https://static.igem.org/mediawiki/2013/f/f1/Mr-igem-sponsors-home.png" alt="Our Sponsors" usemap="#sponsors" />
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    <area shape="rect" coords="0,0,376,80"
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          href="http://www.synmikro.com/" target="_blank" alt="Synmikro" title="Synmikro" />
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    <area shape="rect" coords="406,0,686,80"
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          href="http://www.hessen-trade-and-invest.com/" target="_blank" alt="Hessen Trade & Invest" title="Hessen Trade & Invest" />
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    <area shape="rect" coords="683,0,990,80"
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          href="http://www.abbvie.com/" target="_blank" alt="Abbvie" title="Abbvie" />
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    <area shape="rect" coords="140,85,420,160"
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          href="http://www.healthcare.siemens.com/" target="_blank" alt="Siemens" title="Siemens" />
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    <area shape="rect" coords="523,85,841,160"
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          href="http://www.erasynbio.eu/" target="_blank" alt="ERA SynBio" title="ERA SynBio" />
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Latest revision as of 18:42, 28 October 2013

The iGEM Marburg proudly presents: PHAECTORY

The use of proteins in medical treatment and diagnosis is steadily increasing. Many of these proteins (e.g. antibodies) have a complex biological structure, which complicates their production. Also, these proteins need to be highly pure. Therefore, a major challenge is the development of systems that produce complex proteins with high purity - best at low costs!

The sunlight-driven microalgae Phaeodactylum tricornutum has been used for the production of complex proteins. A major advantage of the algae is its ability to secrete proteins directly into the medium. This feature would greatly simplify purification of recombinant proteins, and lower production costs! Here we take advantage of the excellent secretion abilities of P. tricornutum, and make this organism accessible to synthetic biology and the iGEM competition (PHAECTORY).

Furthermore, we used a light-inducible promoter which we have characterized quantitatively in order to control protein expression in PHAECTORY (Light control). Also, we introduced a transferable element to the registry, which allows autonomous targeting of proteins to the inner surface of cell membranes (Improve a Brick). We hope you enjoy reading about our project!

Video Introduction
YouTube Video
Human Practice


Our Sponsors


Our Sponsors Synmikro Hessen Trade & Invest Abbvie Siemens ERA SynBio

Retrieved from "http://2013.igem.org/Team:Marburg"