The iGEM Marburg proudly presents: PHAECTORY

The use of proteins in medical treatment and diagnosis is steadily increasing. Many pharmaceutically relevant proteins, such as antibodies, have a complex biological structure with specific posttranslational modifications. Furthermore, these proteins need to be highly pure because of their use in diagnostics and treatment. Therefore, a major challenge is the development of systems that produce highly pure, posttranslational modified pharmaceutical proteins - best at low costs.

Recently, the sunlight-driven microalgae Phaeodactylum tricornutum has been established as an elegant tool for the production of proteins (PHAECTORY). A major - however yet unchallenged - advantage of this system is the production of advanced proteins with specific posttranslational modifications. A further major advantage is the ability of their direct secretion into the medium, which allows easy purification with low effort and costs. Our mission is to challenge PHAECTORY as a system for the convenient production of antibodies. We want to take advantage of the excellent secretion and ability of posttranslational modification and make the system accessible to following iGEM teams. Have a look on our project.

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