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Team:Heidelberg/NRPSDesignerDB Curation Table
From 2013.igem.org
Project
Notebook
Human Practice
| Pathway (PubMed IDs) | Gene (nuccore ID) | Module | Domain sequence | Donor chirality | A-domain substrate |
|---|---|---|---|---|---|
| Actinomycin (9573200) | acmA (295683927) | 1 | A | - | 4-methyl-3-hydroxyanthranilic acid |
| acmB (295683927) | 2 | C_St-A-T | - | Threonine | |
| 3 | C-A-T-CCOM | L | Valine | ||
| acmC (295683927) | 4 | NCOM-C-A-T | D | Proline | |
| 5 | C-A-NM-T | L | Glycine | ||
| 6 | C-A-NM-T-TE | L, L (TE) | Valine | ||
| ACV (9266851, 21889568, 10715209) | acvA (3117) | 1 | A-T | - | α-Aminoapidic acid |
| 2 | C-A-T | L | Cysteine | ||
| 3 | C-A-T-E-TE | L, D (TE) | Valine | ||
| A47934 (12060705) | staA (21911402) | 1 | A-T | - | 4-Hydroxyphenylglycine |
| 2 | C_gl-A-T-E | D | Tyrosine | ||
| staB (21911402) | 3 | C_gl-A-T-E*-CCOM | D | 3,5-Dihydroxyphenylglycine | |
| staC (21911402) | 4 | NCOM-C_gl-A-T-E | L | 4-Hydroxyphenylglycine | |
| 5 | C_gl-A-T-E | D | 4-Hydroxyphenylglycine | ||
| 6 | C_gl-A-T | D | β-Hydroxytyrosine | ||
| staD (21911402) | 7 | NCOM-C_gl-A-T-C_Xg-TE | L, L (TE) | 3,5-Dihydroxyphenylglycine | |
| Anabaenopeptilide (10931313) | adpA (9715728) | 1 | A-T | - | Gutamine |
| 2 | C-A-T | Threonin | |||
| adpB (9715728) | C-A-T | L | Homotyrosine | ||
| 4 | C-A-T | L | 3-Amino-6-hydroxy-2-piperidone | ||
| 5 | C-A-NM-T | L | Threonin | ||
| 6 | C-A-NM-T | L | Tyrosine | ||
| adpE (9715728) | 6 | OM | - | - | |
| adpD (9715728) | 7 | C-A-T-TE | L, L(TE) | Isoleucine | |
| Arthrofactin (14522057) | arfA (29501264) | 1 | C_St-A-T | - | Leucine |
| 2 | C_du-A-T | D | Aspartic acid | ||
| arfB (29501264) | 3 | C_du-A-T | D | Threonine | |
| 4 | C_du-A-T | D | Leucine | ||
| 5 | C_du-A-T | D | Leucine | ||
| 6 | C-du-A-T | D | Serine | ||
| arfC (29501264) | 7 | C_du-A-T | D | Leucine | |
| 8 | C-A-T | L | Serine | ||
| 9 | C_du-A-T | D | Isoleucine | ||
| 10 | C-A-T | L | Isoleucine | ||
| 11 | C-A-T-TE-TE | L, L (TE) | Apsartic acid | ||
| Bacitracin (9427658) | bacA (4464275) | 1 | A-T | - | Isoleucine |
| 2 | Cy-A-T | L | Cysteine | ||
| 3 | C-A-T | L | Leucine | ||
| 4 | C-A-T-E | L | Glutamic acid | ||
| 5 | C-A-T | D | Isoleucine | ||
| bacB (4464275) | 6 | C-A-T | L | Lysine | |
| 7 | C-A-T-E | L | Ornithine | ||
| bacC (4464275) | 8 | NCOM-C-A-T | D | Isoleucine | |
| 9 | C-A-T-E | L | Phenylalanine | ||
| 10 | C-A-T | D | Histidine | ||
| 11 | C-A-T-E | L | Aspartic acid | ||
| 12 | C-A-T-TE | D, L (TE) | Asparagine | ||
| CDA (12445768) | cdaPSI (24426505) | 1 | C_St-A-T | - | Serine |
| 2 | C-A-T | L | Threonine | ||
| 3 | C-A-T-E | L | Tryptophan | ||
| 4 | C-A-T | D | Aspartic acid | ||
| 5 | C-A-T | L | Aspartic acid | ||
| 6 | C-A-T-E | L | 4-Hydroxyphenylglycine | ||
| cdaPS2 (24426505) | 7 | C_gl-A-T | D | Aspartic acid | |
| 8 | C-A-T | L | Glycine | ||
| 9 | C-A-T-E | L | Asparagine | ||
| cdaPS3 (24426505) | 10 | NCOM-C-A-T | D | Glutamic acid and 3-methylglutamic acid | |
| 11 | C-A-T-TE | L, L (TE) | Tryptophan | ||
| Cyclosporin (8376400, 16895337, 8175682) | simA (440168) | 1 | C_St-A-T | - | D-Alanine |
| 2 | C-A-NM-T | L | Leucine | ||
| 3 | C-A-NM-T | L | Leucine | ||
| 4 | C-A-NM-T | L | Valine | ||
| 5 | C-A-NM-T | L | 2-Butenyl-4-methylthreonine | ||
| 6 | C-A-T | L | α-Aminobutyric acid | ||
| 7 | C-A-NM-T | L | Glycine | ||
| 8 | C-A-NM-T | L | Leucine | ||
| 9 | C-A-T | L | Valine | ||
| 10 | C-A-NM-T | L | Leucine | ||
| 11 | C-A-T | L | Alanine | ||
| Final C-domain predicted probably has TE-domain funtion. deleted | |||||
| Gramicidine (1560782) | gramicidin S synthethase 1 (216277) | 1 | A-T-E | - | Phenylalanine |
| grsB (39371) | 2 | NCOM-C-A-T | D | Proline | |
| 3 | C-A-T | L | Valine | ||
| 4 | C-A-T | L | Ornithine | ||
| 5 | C-A-T-TE | L, L (TE) | Leucine | ||
| Indigoidine | indC (36785405) | 1 | AOxA-T-TE | x | Glutamine |
| Lichenycin (9864322) | licA (3080741) | 1 | C_St-A-T | - | Glutamine |
| 2 | C-A-T | L | Leucine | ||
| 3 | C-A-T-E | L | Leucine | ||
| licB (3080741) | 4 | NCOM-C-A-T | D | Valine | |
| 5 | C-A-T | L | Aspartic acid | ||
| 6 | C-A-T-E | L | Leucine | ||
| licC (3080741) | 7 | NCOM-C-A-T-TE | D, L (TE) | Isoleucine | |
| licTE (3080741) | removed due to unknown function of single TE-domain | ||||
| Syringomycin (9830033) | syrE | 1 | C_St-A-T | - | Serine |
| 2 | C_du-A-T | L | Serine | ||
| 3 | C_du-A-T | D | 2,4-Diaminobutyric acid | ||
| 4 | C_du-A-T | D | 2,4-Diaminobutyric acid | ||
| 5 | C-A-T | L | Arginine | ||
| 6 | C-A-T | L | Phenylalanine | ||
| 8 | C_du-A-T-(deleted)-TE | - | Aspartic acid | ||
| syrB1 | removed due to specialised protein interaction of module fragments | ||||
| Tyrocidine (9352938) | tycA (AF004835) | 1 | A-T-E | - | Phenylalanine |
| tycB (AF004835) | 2 | C-A-T | L | Proline | |
| 3 | C-A-T | L | Phenylalanine | ||
| 4 | C-A-T-E | L | Phenylalanine | ||
| tycC (AF004835) | 5 | C-A-T | L | Asparagine | |
| 6 | C-A-T | L | Glutamine | ||
| 7 | C-A-T | L | Tyrosine | ||
| 8 | C-A-T | L | Valine | ||
| 9 | C-A-T | L | Ornithine | ||
| 10 | C-A-T-TE | L, L (TE) | Leucine | ||
| Zwittermicin A (19098220) | zmaQ (223047469) | 9 | A-T | - | Leucine |
| 10 | C-A-T-TE | L | Methionine | ||
