Team:Heidelberg/NRPS

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                       <h1><span style="font-size:170%;color:#FFCC00;">NRPS.</span><span class="text-muted" style="font-family:Arial, sans-serif; font-size:100%">Get to know the theory.</span></h1>
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                       <h1><span style="font-size:170%;color:#FFCC00;">NRPS.</span><span class="text-muted" style="font-family:Arial, sans-serif; font-size:100%"> Get to know the theory.</span></h1>
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Revision as of 12:42, 21 October 2013

NRPS. Get to know the theory.

Legend

A = Adenylation
C = Condensation
T = Thiolytion
TE = Thioesterase
E = Epimerisation
NM = N-Methylation
OM = O-Methylation

Modular Structure

Peptide bond formation

Stereospecificity

Modifying domains

1. Eisler R, Wiemeyer SN (2004) Cyanide hazards to plants and animals from gold mining and related water issues. Reviews of environmental contamination and toxicology: 21–54.

2. Eisler R (2004) Arsenic hazards to humans, plants, and animals from gold mining. In:. Reviews of environmental contamination and toxicology. Springer. pp. 133–165.

3. Donato DB, Nichols O, Possingham H, Moore M, Ricci PF, et al. (2007) A critical review of the effects of gold cyanide-bearing tailings solutions on wildlife. Environment international 33: 974–984.

4. Tay SB, Natarajan G, bin Abdul Rahim MN, Tan HT, Chung MCM, et al. (2013) Enhancing gold recovery from electronic waste via lixiviant metabolic engineering in Chromobacterium violaceum. Scientific reports 3.

5. Johnston CW, Wyatt MA, Li X, Ibrahim A, Shuster J, et al. (2013) Gold biomineralization by a metallophore from a gold-associated microbe. Nature chemical biology 9: 241–243.

6. Strieker M, Tanović A, Marahiel MA (2010) Nonribosomal peptide synthetases: structures and dynamics. Current opinion in structural biology 20: 234–240.

7. Caboche S, Leclère V, Pupin M, Kucherov G, Jacques P (2010) Diversity of monomers in nonribosomal peptides: towards the prediction of origin and biological activity. Journal of bacteriology 192: 5143–5150.

8. Baltz RH (2011) Function of MbtH homologs in nonribosomal peptide biosynthesis and applications in secondary metabolite discovery. Journal of industrial microbiology & biotechnology 38: 1747–1760.

9. Quadri LE, Weinreb PH, Lei M, Nakano MM, Zuber P, et al. (1998) Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases. Biochemistry 37: 1585–1595.

10. de Jong A, Pietersma H, Cordes M, Kuipers OP, Kok J (2012) PePPER: a webserver for prediction of prokaryote promoter elements and regulons. BMC genomics 13: 299.

11. Reith F, Etschmann B, Grosse C, Moors H, Benotmane MA, et al. (2009) Mechanisms of gold biomineralization in the bacterium Cupriavidus metallidurans. Proceedings of the National Academy of Sciences 106: 17757–17762.

12. Cárcamo J, Ravera MW, Brissette R, Dedova O, Beasley JR, et al. (1998) Unexpected frameshifts from gene to expressed protein in a phage-displayed peptide library. Proceedings of the National Academy of Sciences 95: 11146–11151.

Thanks to