Team:Heidelberg/NRPSDesignerDB Curation Table

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Table 1: Current progress of the manual database curation. Only the consens for curated pathways is displayed. Blue fields indicate a conflict of the different resources.

Pathway
(PubMed IDs)

Gene
(nuccore ID)

Module

Domain sequence

Donor chirality

A-domain substrate

Actinomycin
(9573200)

acmA
(295683927)

1

A

-

4-methyl-3-hydroxyanthranilic acid

acmB
(295683927)

2

C_St-A-T

-

Threonine

3

C-A-T-CCOM

L

Valine

acmC
(295683927)

4

NCOM-C-A-T

D

Proline

5

C-A-NM-T

L

Glycine

6

C-A-NM-T-TE

L, L (TE)

Valine

ACV
(9266851, 21889568, 10715209)

acvA
(3117)

1

A-T

-

α-Aminoapidic acid

2

C-A-T

L

Cysteine

3

C-A-T-E-TE

L, D (TE)

Valine

A47934
(12060705)

staA
(21911402)

1

A-T

-

4-Hydroxyphenylglycine

2

C_gl-A-T-E

D

Tyrosine

staB
(21911402)

3

C_gl-A-T-E*-CCOM

D

3,5-Dihydroxyphenylglycine

staC
(21911402)

4

NCOM-C_gl-A-T-E

L

4-Hydroxyphenylglycine

5

C_gl-A-T-E

D

4-Hydroxyphenylglycine

6

C_gl-A-T

D

β-Hydroxytyrosine

staD
(21911402)

7

NCOM-C_gl-A-T-C_Xg-TE

L, L (TE)

3,5-Dihydroxyphenylglycine

Anabaenopeptilide
(10931313)

adpA
(9715728)

1

A-T

-

Gutamine

2

C-A-T

L | Threonin

adpB
(9715728)

3 | C-A-T

L

Homotyrosine

4

C-A-T

L

3-Amino-6-hydroxy-2-piperidone

5

C-A-NM-T

L

Threonin

6

C-A-NM-T

L

Tyrosine

adpE
(9715728)

6

OM

-

-

adpD
(9715728)

7

C-A-T-TE

L, L(TE)

Isoleucine

Arthrofactin
(14522057)

arfA
(29501264)

1

C_St-A-T

-

Leucine

2

C_du-A-T

D

Aspartic acid

arfB
(29501264)

3

C_du-A-T

D

Threonine

4

C_du-A-T

D

Leucine

5

C_du-A-T

D

Leucine

6

C-du-A-T

D

Serine

arfC
(29501264)

7

C_du-A-T

D

Leucine

8

C-A-T

L

Serine

9

C_du-A-T

D

Isoleucine

10

C-A-T

L

Isoleucine

11

C-A-T-TE-TE

L, L (TE)

Apsartic acid

Bacitracin
(9427658)

bacA
(4464275)

1

A-T

-

Isoleucine

2

Cy-A-T

L

Cysteine

3

C-A-T

L

Leucine

4

C-A-T-E

L

Glutamic acid

5

C-A-T

D

Isoleucine

bacB
(4464275)

6

C-A-T

L

Lysine

7

C-A-T-E

L

Ornithine

bacC
(4464275)

8

NCOM-C-A-T

D

Isoleucine

9

C-A-T-E

L

Phenylalanine

10

C-A-T

D

Histidine

11

C-A-T-E

L

Aspartic acid

12

C-A-T-TE

D, L (TE)

Asparagine

CDA
(12445768)

cdaPSI
(24426505)

1

C_St-A-T

-

Serine

2

C-A-T

L

Threonine

3

C-A-T-E

L

Tryptophan

4

C-A-T

D

Aspartic acid

5

C-A-T

L

Aspartic acid

6

C-A-T-E

L

4-Hydroxyphenylglycine

cdaPS2
(24426505)

7

C_gl-A-T

D

Aspartic acid

8

C-A-T

L

Glycine

9

C-A-T-E

L

Asparagine

cdaPS3
(24426505)

10

NCOM-C-A-T

D

Glutamic acid and 3-methylglutamic acid

11

C-A-T-TE

L, L (TE)

Tryptophan

Cyclosporin
(8376400, 16895337, 8175682)

simA
(440168)

1

C_St-A-T

-

D-Alanine

2

C-A-NM-T

L

Leucine

3

C-A-NM-T

L

Leucine

4

C-A-NM-T

L

Valine

5

C-A-NM-T

L

2-Butenyl-4-methylthreonine

6

C-A-T

L

α-Aminobutyric acid

7

C-A-NM-T

L

Glycine

8

C-A-NM-T

L

Leucine

9

C-A-T

L

Valine

10

C-A-NM-T

L

Leucine

11

C-A-T

L

Alanine

Final C-domain predicted probably has TE-domain funtion. deleted

Gramicidine
(1560782)

gramicidin S synthethase 1
(216277)

1

A-T-E

-

Phenylalanine

grsB
(39371)

2

NCOM-C-A-T

D

Proline

3

C-A-T

L

Valine

4

C-A-T

L

Ornithine

5

C-A-T-TE

L, L (TE)

Leucine

Indigoidine

indC
(36785405)

1

AOxA-T-TE

x

Glutamine

Lichenycin
(9864322)

licA
(3080741)

1

C_St-A-T

-

Glutamine

2

C-A-T

L

Leucine

3

C-A-T-E

L

Leucine

licB
(3080741)

4

NCOM-C-A-T

D

Valine

5

C-A-T

L

Aspartic acid

6

C-A-T-E

L

Leucine

licC
(3080741)

7

NCOM-C-A-T-TE

D, L (TE)

Isoleucine

licTE
(3080741)

removed due to unknown function of single TE-domain

Syringomycin
(9830033)

syrE

1

C_St-A-T

-

Serine

2

C_du-A-T

L

Serine

3

C_du-A-T

D

2,4-Diaminobutyric acid

4

C_du-A-T

D

2,4-Diaminobutyric acid

5

C-A-T

L

Arginine

6

C-A-T

L

Phenylalanine

8

C_du-A-T-(deleted)-TE

-

Aspartic acid

syrB1

removed due to specialised protein interaction of module fragments

Tyrocidine
(9352938)

tycA
(AF004835)

1

A-T-E

-

Phenylalanine

tycB
(AF004835)

2

C-A-T

L

Proline

3

C-A-T

L

Phenylalanine

4

C-A-T-E

L

Phenylalanine

tycC
(AF004835)

5

C-A-T

L

Asparagine

6

C-A-T

L

Glutamine

7

C-A-T

L

Tyrosine

8

C-A-T

L

Valine

9

C-A-T

L

Ornithine

10

C-A-T-TE

L, L (TE)

Leucine

Zwittermicin A
(19098220)

zmaQ
(223047469)

9

A-T

-

Leucine

10

C-A-T-TE

L

Methionine
Thanks to

Retrieved from "http://2013.igem.org/Team:Heidelberg/NRPSDesignerDB_Curation_Table"