Team is registered! </p> <p> Judging form is completed and submitted! </p> <p> Project description of the Philosopher's Stone online! <span href="#" class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right" style="font-size: 11px;" data-trigger='click', data-title="Project description", data-content='Numerous non-ribosomal peptides such as antibiotics, chelators of metals, dyes and detoxificating enzymes are produced in an alternative ribosome-independent pathway as secondary metabolites, found in fungi and various bacteria. The chain of modules the enzyme - called non-ribosomal peptide synthetase (NRPS) - consists of, subsequently adds a defined amino acid to build a template-independent peptide chain. Every module’s sequence of subdomains furthermore encodes for possible chemical modifications of the amino acid.

We will investigate modularity of the NRPS systems giving rise to the assembly of novel, engineered synthetases and subsequent synthesis of artificial non-ribosomal peptides. Currently, we are establishing the introduction of different NRPS pathways into E. coli. Our aim is to prove interchangeability of NRPS modules and domains from different host organisms. Smaller peptide synthetases, e.g. producing dyes, are used for the exchange of domains, whereas more complex synthetases, e.g. producing antibiotics, were chosen to investigate module exchangeability.

We wish to share the enormous potential of non-ribosomal peptide synthetases with the iGEM community by establishing a standard system for these synthetases, supported by an implemented software framework. Thereby, we are going to simplify manufacturing and applicability of non-ribosomal peptides in order to offer a cost- and energy-efficient alternative for the synthesis of biomolecules. As secondary metabolites, these peptides play important roles in basic research (such as dyes), pharmaceutical development (such as antibiotics) and recycling (such as chelators). '>

Poster is prepared for the European Jamboree in Lyon! </p> <p> New standard BioBrick is documented! </p> </div> </div> </div>

</h8>

                   <p> New BioBricks are characterized! </p>

                   <p> New BioBricks are submitted! </p>

                    <p>  Implications for ethics are pointed out! </p>

                   <p> Functions of existing BioBricks were improved! <span   href="#" class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right" style="font-size: 11px;"data-trigger='click', data-title="Improved BioBricks", data-content='Functions of three existing BioBricks were improved: 
 
 1) We annotated the PPTase on [Part, link zur registry]. By submitting additional PPTases to the parts registry, we expanded apllications of PPTases. 
 
 2) We identified a missing sequence in the backbone pSB4K5 from the spring distribution of 2012. 

 3) We further characterized the toxicity of [Part, link zur registry], an exporter in E. coli. '></p> </span>

                    <p>  We helped other iGEM teams! </p> 

                    <p> Novel approach to ownership and sharing is described!</p>  

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           <p>  Improve the function of an existing BioBrick Part or Device </p> 

               <p>Have a look on our different parts! </p> 

                <p>  Thank you for the great help! </p>

</div>

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